For SAP S/4HANA (on-premise), an additional parameter should be added to the runtime destination. Watch the following video to learn how to add a parameter to the SAP BTP destination:
The following parameter is mentioned in the video and is included here for your reference:
Additional Parameter for Runtime Destination:
NOTIF_SERVICEPATH = /sap/opu/odata4/iwngw/notification/default/iwngw/notification_srv/0001